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目的探讨2型糖尿病(DM)患者C-反应蛋白(CRP)与纤维蛋白原(FIB)、体重指数(BM I)间的关系。方法对92例2型DM患者和63名健康者同时检测CRP、FIB并测量他们的身高、体重。结果2型DM患者的CRP、FIB、BM I均明显升高,与正常对照组差异有显著性(P<0.01)。CRP同BM I(r=0.412,P<0.001)、FIB(r=0.735,P<0.001)呈正相关,同时对CRP与FIB的实验数据进行回归分析(F=105.96,P<0.001),结果与国外报道的2型DM患者的CRP是FIB的独立预测因子的结论相一致。结论CRP为2型DM的病因、治疗效果及其大血管并发症的早期诊断、预防、治疗及预后评价手段提供了理论依据,定期监测2型DM患者血清中的CRP浓度有重要的临床价值。
Objective To investigate the relationship between C-reactive protein (CRP), fibrinogen (FIB) and body mass index (BM I) in type 2 diabetic patients. Methods 92 patients with type 2 DM and 63 healthy people were tested for CRP and FIB at the same time and their height and weight were measured. Results The levels of CRP, FIB and BM I in type 2 DM patients were significantly higher than those in normal controls (P <0.01). CRP was positively correlated with BM I (r = 0.412, P <0.001) and FIB (r = 0.735, P <0.001). The CRP and FIB data were analyzed by regression analysis (F = 105.96, P <0.001) Foreign reports of type 2 DM patients with CRP are independent predictors of FIB conclusion. Conclusion CRP provides a theoretical basis for the etiology and therapeutic effect of type 2 DM as well as early diagnosis, prevention, treatment and prognosis evaluation of macrovascular complications. It is of great clinical value to periodically monitor the concentration of CRP in the serum of type 2 DM patients.