最近,笔者从雷公滕总甙(TⅡ)中筛选出具有抗生育活性,而无明显免疫抑制作用的单体T_9。实验用NIH雄性小鼠,由胃针喂服T_9(混悬于1％甲基纤维素)0.1mg/(kg·d),6周,对照组喂等量1％甲基纤维素,动物拉颈处死后,取心、肝和肾作病理检查.左侧睾丸和附睾用Bouin液固定,PAS染色.右侧附睾置生理盐水剪碎、过滤后,取1 ml精子悬浮液加1滴3％福尔马林,涂片,另取1滴精子悬浮 Recently, the author from the thirtong glycosides (T Ⅱ) screening with anti-fertility activity, but no significant immunosuppressive monomer T_9. In experimental NIH male mice, T_9 (suspended in 1% methylcellulose) 0.1mg / (kg · d) was administered by gastric needle for 6 weeks. The control group was fed the same amount of 1% methylcellulose, The neck was sacrificed and the heart, liver and kidney were taken for pathological examination.The testis and epididymis were fixed with Bouin solution and stained with PAS.The right epididymis was cut into normal saline, filtered, and 1 ml of 3% Formalin, smear, another one drop of sperm suspension