在过去几十年中,人们对痛觉加工和调节的基础知识大大增加,但对伤害性感受的错综复杂的分子、细胞和系统机制仍是一知半解,对急慢性疼痛的控制远未令人满意,有效的新型镇痛药、手术靶点以及行为治疗策略少之又少,慢性疼痛的现有疗法也亟待改进。上述情况,不论分析得准确还是悲观,引 In the past few decades, the basic knowledge of the processing and regulation of pain has been greatly increased. However, the complicated molecular, cellular and systemic mechanisms of nociception are still poorly understood. The control of acute and chronic pain is far from satisfactory and effective Of the new analgesics, surgical targets and behavioral therapy strategies are rare, the existing treatment of chronic pain is also an urgent need to be improved. The above situation, whether accurate or pessimistic analysis, cited