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S-(+)2,2-二甲基环丙烷甲酰胺是合成医药和农药的重要中间体,其合成方法主要分为化学合成法和生物催化法。综述了国内外2,2-二甲基环丙烷甲酰胺的合成及拆分方法,并对各种合成方法进行分析对比,其中生物催化合成技术因具有高选择性、高催化效率和环境友好等优点而日益受到重视。生物催化合成法克服了化学合成工艺的缺陷,符合原子经济和可持续发展,具有广阔的发展前景。
S - (+) 2,2-dimethylcyclopropanecarboxamide is an important intermediate in the synthesis of pharmaceuticals and pesticides. The synthetic methods are mainly divided into chemical synthesis and biocatalysis. The synthesis and resolution methods of 2,2-dimethylcyclopropanecarboxamide at home and abroad are reviewed, and various synthetic methods are compared and analyzed. Among them, the biocatalytic synthesis technology has high selectivity, high catalytic efficiency and environmental friendliness Advantages and increasing attention. Biocatalytic synthesis method to overcome the shortcomings of chemical synthesis process, in line with atomic economy and sustainable development, has broad prospects for development.