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1.以汉防已甲素或乙素3毫克/公斤靜脉注射、肌肉注射或灌胃,均可使麻醉猫的血压明显下降,甲素之降压作用較乙素大而持久,甲素靜脉注射时,降压作用急驟而持久,可維持1—5小时;肌肉注射及灌胃时,降压作用較緩慢,但亦甚持久。 2.乙素之降压作用較甲素弱而短暫,靜脉給药之作用較肌肉注射为强,灌胃之降压作用又較肌肉注射为弱。 3.静脉注射甲素或乙素3毫克/公斤,在血压下降的同时,可見暫时性心收縮力減弱;但肌肉注射同样或更大剂量(5毫克/公斤),則不出現心力抑制現象,甲素对心率之影响較少,乙素則往往引起心率減慢,心动电流圖上仅見R波幅度之減小,对P-R間歇及T波等均無影响。 4.甲素及乙素可使脾容积增加,但在血压急剧下降时,則可使脾容积縮小。 5.甲素及乙素均可使离体兎耳血管扩張,直接对平滑肌之抑制作用及神經反射机制均参加在內.甲素之血管扩張作用較乙素及罂粟硷为大而持久。
1. Han anti-A or B 3 mg / kg intravenous injection, intramuscular or gavage can anesthetize the cat’s blood pressure decreased significantly, the role of antihypertensive A large and lasting than B, A vein Injection, the antihypertensive effect of a rapid and lasting, can maintain 1-5 hours; intramuscular injection and gavage, the antihypertensive effect is slower, but also very long. 2. B-type antihypertensive effect than A weak and short-term intravenous administration of the role than intramuscular injection, intragastric administration of antihypertensive effect than intramuscular injection is weaker. 3. Intravenous injection of A or B 3 mg / kg, decreased blood pressure at the same time, we can see temporary cardiac contractility weakened; but intramuscular injection of the same or greater dose (5 mg / kg), there is no cardiac arrest , A small impact on heart rate less, B is often caused by heart rate slowed down, only the R wave amplitude decreases, the PR intermittent and T wave had no effect. 4. A and B can increase the spleen volume, but a sharp decline in blood pressure, you can make the spleen volume reduced. 5. A and B can extubation ear vessels dilated, directly on the inhibition of smooth muscle and neural reflex mechanisms are involved.A vasodilator effect than B and papaverine for large and lasting .