目的　体外研究维甲类化合物的衍生物ATRA对LoVo 结肠癌细胞株的作用。方法　观察ATRA作用下LoVo 细胞的增殖、细胞周期和凋亡。结果　ATRA使细胞增殖抑制,细胞阻滞于G0 /G1 期,高浓度组出现亚“G0/G1 ”峰。ALP比值增高,高浓度组电镜下见凋亡细胞,TDT法测凋亡细胞比例增高,但传6 代后不增加。结论　提示ATRA可诱导LoVo 细胞分化及凋亡,但有一定限度;实验结果为临床应用ATRA 化学预防结肠癌提供理论依据 Objective To study the effect of retinoid ATRA derivatives on LoVo colon cancer cell lines in vitro. Methods The proliferation, cell cycle and apoptosis of LoVo cells treated with ATRA were observed. Results ATRA inhibited cell proliferation, blocked cells in G0 / G1 phase, and sub-G0 / G1 peak appeared in high concentration group. ALP ratio increased, apoptotic cells were observed under electron microscope in high concentration group, and the proportion of apoptotic cells was increased by TDT method, but not increased after 6 passages. Conclusions ATRA can induce LoVo cell differentiation and apoptosis, but there is a certain limit; the experimental results provide a theoretical basis for the clinical application of ATRA chemotherapy in the prevention of colon cancer