基因治疗是目前重要的研究领域,如何使目的基因安全有效地导入靶器官或组织细胞并高效表达是目前亟待解决的问题。近年来,有大量的研究表明,在超声及超声造影剂的作用下,基因转染效率大大提高。本文就近几年在超声及超声造影剂提高转染效率的机制、在体内外的实验及影响因素的研究作一总结。 Gene therapy is an important research field at present, and how to make the target gene safely and effectively be introduced into the target organ or tissue cell and express it with high efficiency is an urgent problem to be solved. In recent years, a large number of studies have shown that gene transfection efficiency is greatly enhanced under the action of ultrasound and ultrasound contrast agents. This article in recent years in ultrasound and ultrasound contrast agent to improve transfection efficiency mechanism in vivo and in vitro experiments and influencing factors to make a summary.