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目的:探索血液灌流(HP)联合血液透析(HD)对慢性肾衰竭(Chronic renal failure,CRF)患者炎症因子及同型半胱氨酸(Hcy)、甲状腺旁素(PTH)、β2-微球蛋白(β2-MG)的影响。方法:选择自2012年10月至2014年9月我院收治的98例CRF患者,按照随机数表法将患者分成HD组和HP联合HD组(HP+HD组),每组49例,两组采用相应疗法治疗。由专业的医师对所有患者治疗前及治疗后1个月、2个月、3个月血清中的炎性因子(IL-1β、IL-6、IL-8、CRP、TNF-α及PCT)及Hcy、PTH、β2-MG水平进行检测并统计分析。结果:与治疗前相比,两组患者治疗后1个月、2个月、3个月血清中的炎症因子及Hcy、PTH、β2-MG水平均不同程度下降,而HP+HD组患者在各个时间点血清中的炎症因子及Hcy、PTH、β2-MG水平均明显低于HD组,且差异均具有统计学意义(P<0.05)。结论:HP联合HD较单独使用HD治疗CRF患者具有更好的疗效,可以明显降低患者体内的炎症因子及Hcy、PTH、β2-MG水平,对于临床上治疗CRF具有重要的指导意义。
Objective: To explore the effects of hemoperfusion (HP) and hemodialysis (HD) on the inflammatory cytokines and the levels of homocysteine (Hcy), thyroid PTH, β2-microglobulin in patients with chronic renal failure (CRF) (β2-MG). Methods: From October 2012 to September 2014, 98 patients with CRF admitted to our hospital were divided into HD group and HP combined HD group (HP + HD group) according to the random number table method, 49 cases in each group, Group using the appropriate treatment. Serum inflammatory cytokines (IL-1β, IL-6, IL-8, CRP, TNF-α and PCT) were measured by professional physicians before treatment and at 1 month, 2 months and 3 months after treatment. And Hcy, PTH, β2-MG levels were detected and statistically analyzed. Results: The levels of inflammatory cytokines and the levels of Hcy, PTH and β2-MG in the two groups were all decreased to different extents at 1 month, 2 months and 3 months after treatment, while those in HP + HD group were significantly lower than those before treatment The levels of inflammatory cytokines, Hcy, PTH and β2-MG in serum at each time point were significantly lower than those in HD group, and the difference was statistically significant (P <0.05). CONCLUSION: HP combined with HD has a better curative effect than HD alone in treating CRF. It can significantly reduce the levels of inflammatory cytokines and Hcy, PTH and β2-MG in patients with CRF, which is of great guiding significance for the clinical treatment of CRF.