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目的:研究丹佛发育筛查测验(DDST)用于维族婴幼儿的筛查效度。方法:80名未见躯体疾病的维族婴幼儿纳入研究。以格塞尔发育诊断量表(Gesell)为效标,进行Gesell和DDST的个别测试。效度评价采用灵敏度、特异度、假阳性率、假阴性率、符合率和工作特征曲线下面积(AUC)。结果:DDST迟缓筛查率为17.50%,语言能区迟缓率最高,占比达56.00%。以Gesell发育商DQ≤75分为切点时,DDST筛查的灵敏度、特异度、假阳性率、假阴性率和符合率分别为100.00%、85.71%、14.29%、0.00和86.25%,AUC为0.93(P<0.01)。以Gesell发育商DQ<85分为切点时,DDST的灵敏度、特异度、假阳性率、假阴性率和符合率分别为69.23%、92.54%、7.46%、30.77%和88.75%,AUC为0.80(P<0.01)。结论:用于筛查Gesell异常诊断的维族婴幼儿时,DDST具有较高筛查价值;用于筛查Gesell可疑诊断的婴幼儿时,DDST筛查能力中等。语言可能影响了DDST的筛查效度,可考虑建立维族常模。
Objective: To study the screening test of Denver Developmental Screening Test (DDST) for Uygur infants. Methods: 80 Uighur infants without physical illness were included in the study. The Gesell test was used as a benchmark to conduct individual tests of Gesell and DDST. Validity evaluation used sensitivity, specificity, false positive rate, false negative rate, coincidence rate and area under the working characteristic curve (AUC). Results: The delayed screening rate of DDST was 17.50%, the slowest rate of speech energy area was the highest, accounting for 56.00%. The sensitivity, specificity, false positive rate, false negative rate and coincidence rate of DDST screening were 100.00%, 85.71%, 14.29%, 0.00 and 86.25%, respectively, when the DQ≤75 was cut off by Gesell’s developers. The AUC was 0.93 (P <0.01). The sensitivity, specificity, false positive rate, false negative rate and coincidence rate of DDST were 69.23%, 92.54%, 7.46%, 30.77% and 88.75%, respectively, and the AUC was 0.80 (P <0.01). CONCLUSIONS: DDST is of high screening value for screening Uighur infants diagnosed with Gesell abnormalities and has moderate screening capacity for screening DDT for Gesell suspected infants. Language may affect the screening of DDST validity, consider the establishment of Uygur norm.