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目的:探讨正常范围内外周血白细胞计数(peripheral white blood cell counts,WBCC)对肥胖者发生代谢综合征(metabolicsyndrome,MS)的预测价值。方法:收集湖南省人民医院体检中心2006年4月～2010年1月体检人群共4067例,排除资料不全者,共2830例纳入研究。其中1367例于1～3年后再次来我院体检。肥胖诊断标准按照2000年国际肥胖工作组规定的亚太地区肥胖标准,其中共有肥胖者1120例。代谢综合征诊断标准采用2004年中华医学会糖尿病学分会关于MS的定义。将325例WBCC正常的肥胖者进行四分位数分组(Q1～Q4),随访1～3年后,比较不同WBCC组别发生MS的风险。结果:1.在1120例肥胖体检人群中,肥胖伴MS者352例,占31.43%。2.325例WBCC正常的肥胖者进行四分位数分组(Q1～Q4),随访1～3年后,Q4组发生MS的风险明显增高(25.32%vs 11.11%,OR=2.712;95%CI:1.149-6.400,P<0.05)。结论:1).肥胖人群中,肥胖伴MS者占31.43%。2).正常范围内WBCC的升高可预测肥胖者MS的发生。
Objective: To investigate the predictive value of peripheral white blood cell counts (WBCC) in the normal range on metabolic syndrome (MS) in obese subjects. Methods: A total of 4067 medical examinations were collected from the physical examination center of Hunan Provincial People’s Hospital from April 2006 to January 2010, 2830 cases were excluded from the study. Among them, 1367 cases come to our hospital again after 1-3 years. Obesity diagnostic criteria in accordance with the 2000 International Obesity Working Group set standards for obesity in the Asia Pacific region, of which 1120 were obese. Metabolic syndrome diagnostic criteria using the 2004 Chinese Medical Association of Diabetes credits on the definition of MS. 325 quartiles of obese WBCC normal subjects were divided into quartiles (Q1 ~ Q4). After 1 to 3 years follow-up, the risk of developing MS in different WBCC groups was compared. Among 1120 obese medical people, 352 cases were obese with MS, accounting for 31.43%. 2.325 cases of normal WBCC obese quartiles (Q1 ~ Q4), followed up for 1-3 years, the risk of MS in Q4 group was significantly higher (25.32% vs 11.11%, OR = 2.712; 95% CI: 1.149 -6.400, P <0.05). Conclusion: 1) Among obese people, obese patients with MS accounted for 31.43%. 2) The rise of WBCC in the normal range can predict the occurrence of obese MS.