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目的:观察健脾理气中药联合肝动脉介入化疗和三维适形放疗治疗肝癌的临床疗效和毒副反应。方法:对27例肝癌患者,先采用肝动脉介入化疗1-3次,再进行三维适形放疗计划,并配合中药治疗,采用健脾理气法(以党参、白术、茯苓、八月札、白花蛇舌草为基本方)为主的汤剂内服。结果:PR 4例,MR 7例,SD 16例,无CR、PD病例;毒副反应有肝功能异常1例,上消化道出血3例,Ⅰ-Ⅱ度骨髓功能抑制16例,发热1例。结论:健脾理气中药联合肝动脉介入化疗和三维适形放疗是治疗肝癌安全、有效的方法之一。
OBJECTIVE: To observe the clinical effects and toxicities of Jianpiqiqi combined with transcatheter arterial chemoembolization and three-dimensional conformal radiotherapy in the treatment of liver cancer. Methods: Twenty-seven patients with hepatocellular carcinoma were treated with hepatic artery interventional chemotherapy for 1-3 times, followed by three-dimensional conformal radiotherapy, combined with traditional Chinese medicine (TCM) treatment. The methods of invigorating the spleen and invigorating qi (Codonopsis, Atractylodes, Poria, August, Diffusae as the basic side) based decoction orally. Results: There were 4 cases of PR, 7 cases of MR and 16 cases of SD without CR and PD. There were 1 case of liver dysfunction, 3 cases of upper gastrointestinal bleeding, 16 cases of Ⅰ-Ⅱ degree myelosuppression and 1 case of fever . Conclusion: Jianpiqiqi traditional Chinese medicine combined with transcatheter arterial chemoembolization and three-dimensional conformal radiotherapy is one of the safe and effective methods for the treatment of liver cancer.