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目的:考察奥硝唑氯化钠注射液与头孢替唑钠配伍的稳定性。方法:采用紫外分光光度法,考察不同时间配伍液中2种药物的含量变化及配伍液的不溶性微粒检测,并观察配伍液外观和pH的变化。结果:在室温(25℃)下,8h内配伍液澄明,奥硝唑及头孢替唑钠含量及pH值基本无改变,配伍液色泽无变化。结论:奥硝唑氯化钠注射液与头孢替唑钠配伍8h内是稳定的。
Objective: To investigate the stability of compatibility of ornidazole and sodium chloride injection with ceftezole sodium. Methods: UV spectrophotometry was used to investigate the changes of the contents of two drugs in the compatibility solution at different times and the detection of insoluble particles in the compatibility solution. The appearance and pH of the compatibility solution were also observed. Results: Under the condition of room temperature (25 ℃), the compatibility of the solution was clear within 8h, the contents of ornidazole and ceftezole sodium and pH value were almost unchanged, and the color of the compatibility liquid did not change. Conclusion: Ornidazole sodium chloride injection and ceftezole sodium compatibility within 8h is stable.