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[目的]探讨肥胖与重度反流性食管炎(RE)的相关性。[方法]采用配对病例对照研究方法,以新疆自治区人民医院消化内科2011年1月~2012年12月经胃镜明确诊断的重度RE患者124例为病例组,同期胃镜检查正常或轻度慢性浅表性胃炎124例为对照组。以体质指数(BMI)、腰围(WC)和腰臀比(WHR)作为肥胖检测指标,用多变量回归分析重度RE的危险因素。[结果]病例组BMI、WC及WHR均值均大于对照组(P<0.001)。校正BMI、WC及WHR进行多变量Logistic回归分析发现重度RE发生与腰臀比有明显相关性(P=0.001,OR=4.578,95%CI:1.875~11.174)。[结论]增加腰臀比可能增加重度RE发生率。
[Objective] To investigate the correlation between obesity and severe reflux esophagitis (RE). [Methods] A matched case-control study was conducted in 124 patients with severe RE diagnosed by gastroscopy from January 2011 to December 2012 in Department of Gastroenterology, People’s Hospital of Xinjiang Uygur Autonomous Region. The patients were treated by gastroscopy for the same period or mild chronic superficial 124 cases of gastritis as control group. Body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) were used as indexes of obesity. Multivariate regression was used to analyze the risk factors of severe RE. [Results] The mean values of BMI, WC and WHR in case group were higher than those in control group (P <0.001). Multivariate Logistic regression analysis of corrected BMI, WC, and WHR revealed a significant association between severe RE and waist-to-hip ratio (P = 0.001, OR = 4.578, 95% CI: 1.875-11.174). [Conclusion] Increasing waist-hip ratio may increase the incidence of severe RE.