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本文利用因素分析方法及3个月的配对补铁试验,确立了缺铁性贫血(Iron Deficiency Anemia,IDA)与智能发育的关系。 选择6～36月龄婴幼儿333名进行社会调查、体格检查、血液学检测及智能发育商(Deveopmental Quotient,DQ)的测定。结果表明,IDA患儿的DQ(95.32±9.24)明显低于正常儿(101.62±10.28),P<0.01。以IDA为一个独立变量,对婴幼儿的DQ进行多元逐步回归分析表明,IDA以第七位被纳入方程,对DQ作用显著,两者呈负相关,说明在控制混杂因素影响的情况下,IDA对DQ仍作用显著。配对补铁试验先一步证实缺铁对婴幼儿智能发育的不良作用,IDA患儿补铁3个月后,Hb平均升高1.53g/dL,红细胞内游离原卟啉(Free Erythrocyte Protoporphyrin,FEP)及血清铁蛋白(Serum Ferritin,SF)均恢复正常,DQ较补铁前明显升高(P<0.01),平均升高12.47,而服用安慰剂的IDN患儿及非缺铁儿童实验前后各项指标均无明显变化,说明通过补铁治疗,可使IDN患儿的智能发育恢复正常。
In this paper, the relationship between iron deficiency (IDA) and intelligence development was established by factor analysis and three-month matching iron supplementation. A total of 333 infants aged 6 ~ 36 months were selected for social survey, physical examination, hematology test and Deveopmental Quotient (DQ). The results showed that the DQ of children with IDA (95.32 ± 9.24) was significantly lower than that of normal children (101.62 ± 10.28), P <0.01. IDA as an independent variable, multiple stepwise regression analysis of infant DQ showed that IDA is included in the equation seventh, a significant effect on DQ, the two were negatively correlated, indicating that in the control of confounding factors, IDA DQ still significant effect. Paired iron test first confirmed the adverse effects of iron deficiency on the intelligent development of infants and young children, IDA children with iron 3 months after the average Hb increased 1.53g / dL, erythrocyte free protoporphyrin (Free Erythrocyte Protoporphyrin, FEP) And serum ferritin (SF) returned to normal. DQ was significantly higher than that before iron supplementation (P <0.01), with an average increase of 12.47. Both placebo-treated and non-iron-deficient children No significant changes in indicators, indicating that treatment of iron supplementation, IDN can make children’s intelligence development returned to normal.