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据《Ann Intern Med》2001牛135卷第6期报道 成功地使用药物治疗戒烟后常常再次吸烟。以往的研究还没有验证过专门用于防止再次吸烟的长期药物治疗。为了评估bupropion对防止再次吸烟的效果,美国明尼苏达州Rocheste市Mayo诊所尼古丁研究所J.Taylor Hays博士等,对784名每天至少吸烟15支、接受劝导实施戒烟的社区健康志愿者进行了随机安慰剂对照试验。所有参加者接受持续释放开放标签的bupropion300mg/d,共7周;然后随机指定接受bupropion300mg/d或安慰剂,
According to Ann Intern Med 2001, Volume 135, Number 6, it is reported that smoking is often smoked again after successfully using medications to stop smoking. Previous studies have not validated long-term medication specifically designed to prevent smoking again. To assess the effect of bupropion on preventing smoking, Dr. J. Taylor Hays, a Nicotine Institute for Mayo Clinic in Rocheste, Minn., Conducted a randomized placebo of 784 community-based health volunteers who smoked at least 15 cigarettes per day and were counseled for smoking cessation Control test. All participants received a sustained release of open-label bupropion 300 mg / d for 7 weeks; then randomized to receive bupropion 300 mg / d or placebo,