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血小板输注已成为临床上不可或缺的重要支持疗法,但在临床实践中发现,一些长期反复输注血液制品的患者,发生了血小板输注无效(platelet transfusion refractoriness,PTR),不但影响了治疗效果,严重的出血可能危及患者的生命~([1])。免疫因素是导致血小板输注无效的最主要原因之一,其中HLA-I类抗体是最受临床关注的关键因素~([2]),如何为患者提供HLA相合的血小板供者是成功处理免疫性PTR的关键所在。
Platelet transfusion has become an indispensable and clinically important supportive therapy. However, in clinical practice, it has been found that platelet transfusion refractoriness (PTR) has been reported in some patients who have repeatedly re-infused blood products, which not only affects the treatment Effect, severe bleeding may endanger the lives of patients ~ ([1]). Immune factors lead to ineffective platelet transfusion one of the most important, of which HLA-I antibody is the most clinically important key factor ~ ([2]), how to provide patients with HLA-matched platelet donor is the successful treatment of immunity The key to sexual PTR.