特发性获得性纯红细胞再生障碍病例大约有1/2～1/3伴有胸腺瘤。它发生于有其它自身免疫性疾患时,切除胸腺、用免疫抑制剂及血浆交换术可获得良好疗效,提示其发病与免疫学有关。在一些病例,红细胞生成的抑制看来是由体液因素介导的,认为是抗体。这些假定的抗体已显示能对抗红细胞生成素和红细胞的成熟。近报道红细胞生成受到抑制可能是由于抑制性 T 淋巴细胞的作用所致。 About 1 in 2 to 1 in 3 cases of idiopathic acquired pure red cell aplasia have thymoma. It occurs in other autoimmune disorders, the removal of the thymus, with immunosuppressive agents and plasma exchange can obtain good results, suggesting that the incidence of immunological. In some cases, inhibition of erythropoiesis appears to be mediated by humoral factors and is considered an antibody. These putative antibodies have been shown to antagonize the maturation of erythropoietin and erythrocytes. Recently reported inhibition of erythropoiesis may be due to the role of inhibitory T lymphocytes.