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目的 了解中国有偿献血员HIV感染率及其流行因素。方法 对中国中部某县两个村 18～ 5 0岁村民进行HIV感染率调查 ,并进行定群研究。结果 1997年调查了 96 3人 ,发现HIV抗体阳性者 17例 ,HIV感染率为 1.8%。其中有偿献血员 88人 ,15例为HIV抗体阳性 ,HIV感染率为 17.0 % ,显著高于非献血人群 ( 0 .2 % )。 1998年和 2 0 0 0年进行了随访 ,其中HIV抗体阴性人群6 6 8人 ,共随访 1742人年 ,仅 1例出现HIV抗体阳转 ,发病率为每百人年 0 .0 6。阳性人群和阴性人群均有一半人群有肌注史。 13例HIV感染者配偶随访尚未发现HIV抗体阳转者。HIV感染者CD4 细胞计数逐年下降 ,对 5例HIV感染者进行了基因序列分析 ,全部为HIV 1B′亚型毒株 ,基因离散率平均为 2 .4%。结论 中国局部地区有偿献血员中有较高的HIV感染率 ,献血 (浆 )是其感染HIV的主要危险因素 ,在 3年观察期间该地区有偿献血员HIV感染率没有进一步发展 ,但仍应采取相应的措施预防其传播
Objective To understand HIV prevalence and its prevalence in paid blood donors in China. Methods HIV prevalence among 18 ~ 50-year-old villagers in two villages of a county in central China was investigated and the population-based study was conducted. Results A total of 963 people were investigated in 1997, and 17 cases were found HIV positive, with a HIV prevalence rate of 1.8%. Among them, 88 were paid blood donors, and 15 were HIV-positive. The HIV infection rate was 17.0%, significantly higher than that of non-donated people (0.2%). In 1998 and 2000, 668 HIV-negative patients were followed up for a total of 1742 person-years. Only 1 patient was HIV-positive and the incidence rate was 0.06 per 100 person-years. Half of the positive and negative groups had intramuscular histories. 13 cases of HIV-infected spouses follow-up has not been found in HIV antibody positive person. CD4 count of HIV-infected patients declining year by year, 5 cases of HIV-infected persons were gene sequence analysis, all of HIV 1B ’subtype strains, gene dispersion rate of an average of 2.4%. Conclusions There is a high prevalence of HIV infection among paid blood donors in some areas of China. Blood donation (plasma) is the main risk factor for HIV infection. The rate of HIV infection among paid blood donors in this area has not been further developed during the 3-year observation period, but it should still be taken Corresponding measures to prevent its spread