论文部分内容阅读
目的 了解脑梗死患者血清TNF α、IL 1β含量在恢复期和急性期的变化及意义。 方法 运用双抗夹心酶联免疫吸附法 (ELISA)测定血清中TNF α、IL 1β的含量。 结果 急性期、恢复期脑梗死患者血清TNF α、IL 1β水平较对照组显著增高 (P <0 .0 1) ,急性期又较恢复期高 (P <0 .0 5 ,P <0 .0 1) ;增高程度与神经功能缺损程度及梗死体积大小密切相关。结论 TNF α、IL 1β可能参与脑梗死早期的炎症反应及再灌注损伤 ,并在其中起重要作用。
Objective To investigate the changes and significance of serum TNFα and IL-1β in patients with cerebral infarction during recovery and acute phase. Methods Serum levels of TNFα and IL-1β were measured by double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). Results The serum levels of TNFα and IL-1β in acute and convalescent cerebral infarction patients were significantly higher than those in control group (P <0.01), and were significantly higher in acute phase than in convalescent phase (P <0.05), P <0. 0 1); increased degree of neurological deficits and infarct size are closely related. Conclusion TNFα and IL-1β may play an important role in the inflammatory reaction and reperfusion injury in early stage of cerebral infarction.