论文部分内容阅读
目的探讨不同光敏剂诱导的光动力疗法(photodynamic therapy,PDT)在结直肠癌治疗中的应用效果。方法晚期结直肠癌患者120例,随机分为观察组和对照组各60例;2组均采用常规化疗联合PDT,对照组光敏剂应用血卟啉衍生物注射剂,观察组应用5-氨基乙酰丙酸注射剂,治疗周期均为3个月,比较2组症状改善率和总有效率,随访2a,观察2组生存时间及2a生存率。结果观察组症状改善率(93.3%)、总有效率(83.3%)和2a生存率(58.3%)均高于对照组(83.3%、66.7%、38.3%),中位生存时间[(33.29±3.44)个月]长于对照组[(19.78±5.33)个月](P<0.05)。结论与血卟啉衍生物诱导比较,结直肠癌化疗中应用5-氨基乙酰丙酸光敏剂诱导的PDT可有效改善患者症状,提高疗效,延长生存期。
Objective To investigate the effect of different photosensitizer-induced photodynamic therapy (PDT) in the treatment of colorectal cancer. Methods 120 cases of advanced colorectal cancer patients were randomly divided into observation group and control group of 60 cases; 2 groups were treated with conventional chemotherapy combined with PDT, the control group photosensitizer hematoporphyrin derivative injection, the observation group with 5-aminoacetyl-C Acid injection, the treatment period was 3 months, the two groups were compared to improve the rate of symptoms and total effective rate, follow-up 2a, survival time and 2a survival rate were observed. Results The symptom improvement rate (93.3%), total effective rate (83.3%) and 2a survival rate (58.3%) in the observation group were significantly higher than those in the control group (83.3%, 66.7%, 38.3% 3.44) months longer than the control group [(19.78 ± 5.33) months] (P <0.05). Conclusions Compared with the hematoporphyrin derivative induction, PDT induced by 5-aminolevulinic acid photosensitizer can effectively improve the symptoms, improve the curative effect and prolong the survival of patients with colorectal cancer.