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人类Klotho基因位于染色体13q12区域，全长约50 kb。 Klotho基因敲除小鼠表现出多种类似人类衰老的相关表型，并且与肿瘤抑制作用密切相关，其基因表达下调及基因多态性与多种肿瘤易患性之间有明显联系，如肺癌、胃癌、胰腺癌、宫颈癌等，反映其在临床诊疗中的重要应用价值。Klotho基因在少数肿瘤中显示出促癌效应，如卵巢癌，这种促癌效应可能与 Klotho 基因涉及众多信号通路，进而在肿瘤发生、发展中表现出组织特异性有关。“,”Human Klotho gene is localized on chromosome 13q12,spanning over 50 kb.The Klotho knockout mice show a human-like aging-related phenotype.Klotho gene is also closely associated with tumor suppression.The down-regulation of Klotho expression and its polymorphism are related to the susceptibility of many cancers,such as lung cancer,pancreatic cancer,gastric cancer and cervical cancer,which implies its great applicative value in the clinical diagnosis and treatment.However,Klotho also has a carcinogenic effect on certain cancers,for example ovarian cancer,which may be partly owing to its involvement in numerous sig-naling pathways,thus showing tissue specificity in the occurrence and development of cancers.