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对２６例原发肺癌（肺癌组）和３０例非肺癌（非肺癌组）患者的血清和支气管冲洗液（ＢＬＦ）中的癌胚抗原（ＣＥＡ）、铁蛋白（ＦＴ）、唾液酸（ＳＡ）和β２－微球蛋白（β２－Ｍ）进行了检测。结果显示，肺癌组血清ＳＡ、β２－Ｍ和ＢＬＦ中ＳＡ、ＦＴ含量与非肺癌组比较相差不显著（Ｐ＞０．０５）；肺癌组血清ＣＥＡ、ＦＴ和ＮＦ中ＣＥＡ；β２－Ｍ的含量明显高于非肺癌组（Ｐ＜０．０１￣０．００１），其单项检测诊断肺癌的敏感度和特异度分别是５３．５８％、９３．３３％、５０％、８６．６７％，５０％、８０％，６５．３８％、９０％。四项指标联合检测有助于早期肺癌和纤维支气管镜检查阴性肺癌的及时诊断，而纤支镜检查对四项指标均为阴性者有弥补诊断作用。
Carcinoembryonic antigen (CEA), ferritin (FT), sialic acid (SA) in serum and bronchial lavage fluid (BLF) in 26 patients with primary lung cancer (lung cancer group) and 30 non-lung cancer (non-lung cancer group) patients. And β2-microglobulin (β2-M) was tested. The results showed that the levels of SA, FT in serum, β2-M and BLF in lung cancer group were not significantly different from those in non-lung cancer group (P>0.05). The levels of serum CEA, FT and NF in CEA and β2-M in lung cancer group were significantly different. The sensitivity and specificity of single detection in the diagnosis of lung cancer were 53.58%, 93.33%, 50%, 86.67%, respectively, which were significantly higher than those in the non-lung cancer group (P < 0.01 ~ 0.001). %, 80%, 65.38%, 90%. Combined detection of the four indicators can help timely diagnosis of early-stage lung cancer and fibrobronchoscopy-negative lung cancer, and bronchoscopy can compensate for the diagnosis of all four indicators.