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组蛋白赖氨酸特异性去甲基化酶1(LSD1)能够催化氧化去除组蛋白H3K4和H3K9的单、双甲基,该酶在多种恶性肿瘤组织中高度表达,与肿瘤的发生发展密切相关,是一个新兴的肿瘤治疗靶标。综述LSD1的结构、催化机制以及近年来LSD1抑制剂的研究进展。
The histone lysine-specific demethylase 1 (LSD1) catalyzes the oxidative removal of mono- and di-methyl groups of histone H3K4 and H3K9, which is highly expressed in various malignant tumors and closely related to the development of tumors Related, is a new cancer treatment target. The structure, catalytic mechanism of LSD1 and the progress of LSD1 inhibitors in recent years are reviewed.