论文部分内容阅读
目的研究2型糖尿病(DM)大血管病变(MA)的特点、相关危险因素及临床意义。方法将316例2型DM患者分为有MA组174例,其中缺血性心脏病(IHD)患者80例、脑血管病变(CVD)患者55例、周围血管病变(PVD)患者64例;非MA组142例。所有患者均做口服糖耐量试验(OGTT)、胰岛素释放试验,检测空腹血糖(FPG)、2小时血糖(2h PG)、空腹血清胰岛素(FINS)水平,根据结果计算胰岛素抵抗指数(HOMA-IR);检测瘦素(LEP)、白介素-6(IL-6)、C反应蛋白(CRP)等,对2型DM大血管病变的临床数据进行比较及回归分析。结果(1)MA组的年龄、高血压患病率与非MA组比较有显著性差异(P<0.01);(2)MA组IL-6、CRP与非MA组比较有显著性差异(P<0.05,P<0.01),MA组LEP与非MA组比较无显著性差异(P>0.05);(3)回归分析显示,高血压、年龄是2型DM病患者MA的独立危险因素(P<0.01)。结论年龄、高血压是2型DM患者发生MA的独立危险因素;2型DM合并MA者存在低水平慢性炎症;积极控制血压可能对减少其大血管事件的发生有重要意义。
Objective To study the characteristics, related risk factors and clinical significance of type 2 diabetes (DM) macroangiopathy (MA). Methods A total of 316 patients with type 2 DM were divided into MA group (174 cases), including 80 cases of ischemic heart disease (IHD), 55 cases of cerebrovascular disease (CVD) and 64 cases of peripheral vascular disease (PVD) MA group of 142 cases. All patients underwent oral glucose tolerance test (OGTT), insulin release test, fasting blood glucose (FPG), 2-hour blood glucose (2h PG) and fasting serum insulin (FINS) (LEP), interleukin-6 (IL-6) and C-reactive protein (CRP) were detected by ELISA. The clinical data of type 2 diabetic macropathy were compared and analyzed. Results (1) There was a significant difference in the age and the prevalence of hypertension between the MA group and the non-MA group (P <0.01). (2) There was a significant difference between the MA group and the non-MA group (P <0.05, P <0.01). There was no significant difference between MA group and non-MA group (P> 0.05). (3) The regression analysis showed that hypertension and age were the independent risk factors of MA in type 2 DM patients <0.01). Conclusions Age and hypertension are independent risk factors of MA in type 2 diabetes mellitus patients. Low-grade chronic inflammation exists in type 2 DM patients with MA. The positive control of blood pressure may be of great significance in reducing the occurrence of macrovascular events.