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目的:探讨中医五音疗法在肿瘤内科化疗患者中的应用效果。方法:采用便利抽样法，选取2017年2月—2019年2月河北北方学院附属第一医院150例肿瘤内科行2个周期化疗的患者为研究对象，根据随机及患者自愿原则将其分为观察组（75例）和对照组（75例）。对照组予以常规化疗与普通音乐干预，观察组在化疗基础上予以中医五音疗法。比较两组化疗前后采用Piper疲乏量表（PFS）评价患者癌因性疲乏程度，采用平均动脉压（MAP）、心率、一氧化氮、超氧化物歧化酶（SOD）评估患者应激状态，采用汉密尔顿焦虑量表（HAMA）、汉密尔顿抑郁量表（HAMD）、心理弹性量表简化表（CD-RISC）评估患者心理状态，采用癌症生活质量评估问卷（QLQ-30）评估患者生活质量，比较两组患者不良反应发生率。结果:观察组化疗1周、化疗2周时PFS评分低于对照组，差异有统计学意义（n P<0.05）；观察组化疗2周一氧化氮水平低于对照组，SOD水平高于对照组，两组比较差异有统计学意义（n P<0.05）；观察组化疗2周时HAMA评分、HAMD评分低于对照组，CD-RISC评分高于对照组，差异有统计学意义（n P<0.05）；观察组化疗1周、化疗2周QLQ-30评分高于对照组，差异有统计学意义（n P<0.05）；观察组化疗后1个月内恶心、呕吐、骨髓抑制发生率低于对照组，差异有统计学意义（n P<0.05）。n 结论:中医五音疗法可有效减轻肿瘤内科化疗患者癌因性疲乏、应激状态，提高其心理韧性和生活质量，减少不良反应，值得在临床推广实践。“,”Objective:To explore the effects of traditional Chinese medicine five-tone therapy among chemotherapy patients in Department of Oncology.Methods:From February 2017 to February 2019, convenience sampling was used to select 150 patients who underwent two cycles of chemotherapy in the Department of Oncology at the First Affiliated Hospital of Hebei North University as the research object. All patients were divided into observation group (75 cases) and control group (75 cases) according to the random principle and patient voluntary principle. Control group carried out routine chemotherapy and ordinary music intervention, and observation group implemented traditional Chinese medicine five-tone therapy on the basis of chemotherapy. The Piper Fatigue Scale (PFS) was used to evaluate the cancer-related fatigue in two groups before and after chemotherapy; the mean arterial pressure (MAP) , heart rate, nitric oxide and superoxide dismutase (SOD) were used to assess the stress of patients; the Hamilton Anxiety Scale (HAMA) , Hamilton Depression Scale (HAMD) and the Connor-Davidson Resilience Scale (CD-RISC) were adopted to assess the mental state of patients; the Quality of Life Questionnaire-30 (QLQ-30) was used to evaluate the quality of life of patients; the incidence of adverse reactions in patients between two groups was also compared.Results:The PFS scores of observation group one week and two weeks after chemotherapy were lower than those of control group, the differences were statistically significant (n P<0.05) . The nitric oxide of observation group two weeks after chemotherapy was lower than that of control group, and SOD of observation group was higher than that of control groupwith statistical differences (n P<0.05) . Two weeks after chemotherapy, the scores of HAMA and HAMD of observation group were lower than those of control group, and the score of CD-RISC was higher than that of control group, the differences were statistically significant (n P<0.05) . The scores of QLQ-30 of observation group one week and two weeks after chemotherapy were higher than those of control group with statistical differences (n P<0.05) . The incidence of nausea, vomiting and bone marrow suppression in observation group was lower than that in control group within one month after chemotherapy, and the difference was statistically significant (n P<0.05) .n Conclusions:Traditional Chinese medicine five-tone therapy can effectively reduce cancer-related fatigue and stress in patients undergoing chemotherapy in the Department of Oncology, improve their mental toughness and quality of life, and reduce adverse reactions which is worthy of clinical promotion and practice.