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通过探讨不同负荷有氧运动对大鼠动脉粥样硬化发生发展过程中心肌CGRP、AngⅡ含量的影响,为制定动脉粥样硬化运动处方提供一定的理论参考。运用雄性Wistar大鼠40只,随机分为正常对照组(NC,n=10);动脉粥样硬化组(AS,n=10);动脉粥样硬化+60 min有氧运动组(ASAT1,n=10);动脉粥样硬化+120min有氧运动组(ASAT2,n=10)。建立大鼠动脉粥样硬化和有氧运动模型。放免法测定心肌中CGRP和AngⅡ含量。结果发现:AS组与NC组相比,心肌CGRP显著降低(P<0.05),AngⅡ显著升高(P<0.05)。ASAT1、ASAT2两组与AS组相比,心肌CGRP有升高趋势,ASAT1组AngⅡ显著低于AS组(P<0.05)。ASAT2与ASAT1相比,心肌AngⅡ显著升高。表明:1)60 min有氧训练可以使大鼠动脉粥样硬化发生发展过程中心肌组织CGRP升高,AngⅡ降低,延缓动脉粥样硬化的进程。2)120 min有氧训练与60 min有氧训练相比,大鼠心肌CGRP降低,AngⅡ升高。从某种程度说明较长时间有氧运动并不能进一步改善动脉粥样硬化。
By discussing the effect of different load aerobic exercise on the content of CGRP and AngⅡ in the development of atherosclerosis in rats, this study may provide some theoretical references for the development of exercise prescription of atherosclerosis. Forty male Wistar rats were randomly divided into normal control group (NC, n = 10), atherosclerosis group (AS, n = 10), atherosclerosis +60 min aerobic exercise group = 10); atherosclerosis + 120min aerobic exercise group (ASAT2, n = 10). To establish a rat model of atherosclerosis and aerobic exercise. The levels of CGRP and AngⅡ in myocardium were determined by radioimmunoassay. The results showed that compared with NC group, the CGRP of myocardium in AS group was significantly lower (P <0.05) and Ang Ⅱ was significantly higher (P <0.05). The levels of CGRP in ASAT1 and ASAT2 groups were higher than those in AS group, while AngⅡ in ASAT1 group was significantly lower than that in AS group (P <0.05). Compared with ASAT1, ASAT2 significantly increased myocardial Ang Ⅱ. The results showed that: 1) 60 min aerobic training can increase the level of CGRP, decrease Ang Ang, and delay the process of atherosclerosis during the development of atherosclerosis in rats. 2) 120 min aerobic training Compared with 60 min aerobic training, CGRP decreased and Ang II increased in the myocardium. To some extent, that a longer period of aerobic exercise and can not further improve atherosclerosis.