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目的:抗甲状腺药物(简称ATD)治疗弥漫性毒性甲状腺肿(简称GD)的过程中,出现粒细胞缺乏症,分析监测手段、观察治疗效果。方法:收集由于服用ATD引起粒细胞缺乏而需住院的GD患者20例,进行回顾性分析。结果:本组均给予药物积极治疗,其中18例于用药后3~14 d内外周血粒细胞计数恢复正常、体温正常,感染控制。结论:对于粒细胞缺乏症患者,应用有效抗生素,重组人粒细胞集落刺激因子,糖皮质激素非常重要。
Objective: Anti-thyroid drugs (referred to as ATD) in the treatment of diffuse toxic goiter (referred to as GD) process, the emergence of agranulocytosis, analysis of monitoring tools to observe the therapeutic effect. Methods: Twenty patients with GD who were hospitalized for ATG-induced agranulocytosis were retrospectively analyzed. Results: All the patients in this group were treated with active drugs. Among them, the peripheral blood neutrophil count returned to normal in 18 cases within 3 ~ 14 days after treatment. The body temperature was normal and the infection was controlled. Conclusion: In patients with agranulocytosis, the application of effective antibiotics, recombinant human granulocyte colony-stimulating factor, glucocorticoid is very important.