动脉粥样硬化症与遗传、高血脂、高血压、吸烟和糖尿病等易患因素的关系为众所周知。研究发现,动脉粥样硬化进程受动脉壁内钙含量增高而加速,近来还观察到阻止钙进入动脉壁内的钙拮抗剂能减轻实验性动脉粥样硬化模型。发病机理脂肪条索仍被认为是动脉粥样硬化病灶形成纤维斑块的前体,它与单核细胞(巨噬细 The relationship between atherosclerosis and predisposition factors such as inheritance, hyperlipemia, hypertension, smoking and diabetes is well known. The study found that progression of atherosclerosis is accelerated by increased calcium content in the arterial wall, and recently it has also been observed that calcium antagonists that prevent calcium from entering the arterial wall reduce the experimental atherosclerosis model. Pathogenesis Fatty cords are still considered to be precursors of atherosclerotic lesions that form fibrous plaques and interact with monocytes (macrophages