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[目的]探讨HSP60和MMP9在胃癌中的表达及与临床病理参数的关系,评价HSP60和MMP9在胃癌发生、发展中的作用及其意义。[方法]采用免疫组化方法检测HSP60和MMP9在65例胃癌患者手术标本中及在20例相应癌旁正常组织中的表达情况。[结果]HSP60和MMP9在胃癌组织中的阳性率分别为63.1%、67.8%,明显高于在正常组织中的表达,差异有统计学意义(P<0.01)。HSP60与胃癌的浸润深度、淋巴结转移和临床分期有关,MMP9与胃癌的浸润深度、分化程度、临床分期、淋巴结转移有显著的相关性,HSP60与MMP9的表达呈正相关(r=0.289 P=0.019)。[结论]HSP60和MMP9表达与胃癌的临床分期、淋巴结转移有关,二者的共同作用可能是促进胃癌恶性进展的重要因素,同时检测HSP60和MMP9的表达水平将有助于判断胃癌的恶性程度及其预后。
[Objective] To investigate the expression of HSP60 and MMP9 in gastric cancer and its relationship with clinicopathological parameters, and to evaluate the role and significance of HSP60 and MMP9 in the occurrence and development of gastric cancer. [Method] Immunohistochemistry was used to detect the expression of HSP60 and MMP9 in 65 cases of gastric cancer specimens and 20 cases of corresponding normal tissues. [Results] The positive rates of HSP60 and MMP9 in gastric cancer tissues were 63.1% and 67.8%, respectively, which were significantly higher than those in normal tissues (P <0.01). The expression of HSP60 was positively correlated with the expression of MMP9 (r = 0.289 P = 0.019). There was a significant correlation between the expression of HSP60 and the invasiveness, lymph node metastasis and clinical stage of gastric cancer. The expression of HSP60 was positively correlated with the depth of invasion, differentiation, clinical stage and lymph node metastasis . [Conclusion] The expressions of HSP60 and MMP9 are related to the clinical stage and lymph node metastasis of gastric cancer. The combined effect of both may be an important factor to promote the malignant progression of gastric cancer. Simultaneously detecting the expressions of HSP60 and MMP9 will be helpful in judging the malignant degree of gastric cancer and Its prognosis.