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目的:探讨不同免疫球蛋白(Ig)类型的多发性骨髓瘤(MM)患者血脂变化的临床意义。方法:检测MM患者60例,其中IgG型30例,IgA型12例,IgD型5例,轻链型13例。对照组为健康体检者30例的胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和总胆汁酸(TBA)水平,并进行统计学分析。结果:MM患者与对照组相比TC、LDL-C、HDL-C和TBA水平均差异有统计学意义(均P<0.01),而TG水平比较差异无统计学意义(P>0.05)。IgG和IgA型MM患者的TC、TBA、HDL-C和LDL-C水平和轻链型患者比较均差异有统计学意义(均P<0.05);TG水平和轻链型患者比较差异无统计学意义(P>0.05)。IgD型MM患者和轻链型患者比较差异无统计学意义(P>0.05)。结论:检测血脂变化可作为MM患者免疫球蛋白分型的一个辅助实验室诊断手段。
Objective: To investigate the clinical significance of the changes of serum lipids in patients with multiple myeloma (MM) of different immunoglobulin (Ig) types. Methods: Sixty patients with MM were detected, of which 30 were IgG, 12 were IgA, 5 were IgD and 13 were light chain. In the control group, the levels of cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and total bile acid (TBA) , And statistical analysis. Results: Compared with the control group, the levels of TC, LDL-C, HDL-C and TBA in MM patients were significantly different (all P <0.01), while there was no significant difference in TG levels between MM patients and controls (P> 0.05). The levels of TC, TBA, HDL-C and LDL-C in patients with IgG and IgA MM were significantly different from those in patients with mild to light (all P <0.05). There was no significant difference between TG and light chain patients Significance (P> 0.05). There was no significant difference between IgD MM patients and light chain patients (P> 0.05). Conclusion: The detection of blood lipid changes can be used as an auxiliary laboratory diagnostic method for immunoglobulin typing in MM patients.