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目的探索安徽农村地区影响高同型半胱氨酸型高血压(H型高血压)发生的基因和环境危险因素。方法在安徽农村地区入选226名高血压患者,测定N5,10-亚甲基四氢叶酸还原酶(MTHFR)C677T基因型和血浆同型半胱氨酸(Hcy)水平。结果 (1)所调查的高血压人群男性Hcy水平显著高于女性(P<0.01);男性H型高血压患病率(71.3%)高于女性(48.0%)。(2)TT基因型与CC+CT基因型相比,Hcy水平显著增加,H型高血压的比例显著增加。(3)其他相关变量与Hcy水平的多元线性回归模型及与H型高血压多因素Logistic回归模型分析,均未发现年龄、吸烟、饮酒和体质指数与Hcy水平有显著性的相关(均有P>0.05)。结论安徽农村地区高血压人群中MTHFRC677T基因突变可能是H型高血压发病的重要遗传因素且存在性别差异,建议该人群应该尽早做相关的检测以检查是否发生高同型半胱氨酸血症。
Objective To explore the genetic and environmental risk factors that affect the occurrence of homocysteine-type hypertension (Hypertension) in rural Anhui. Methods A total of 226 hypertensive patients were enrolled in the rural areas of Anhui Province. The genotypes of N5, 10-methylenetetrahydrofolate reductase (MTHFR) C677T and plasma homocysteine (Hcy) levels were determined. Results (1) The prevalence of Hcy in men with hypertension was significantly higher than that in women (P <0.01). The prevalence of Hypertension in male was 71.3% higher than that in women (48.0%). (2) Compared with CC + CT genotype, TT genotype significantly increased the level of Hcy and the proportion of Hypertension. (3) No significant correlations were found between age, smoking, drinking, body mass index and Hcy levels in both multivariate linear regression model of other related variables and Hcy levels and multivariate Logistic regression model of Hypertension (both P > 0.05). Conclusion Mutation of MTHFRC677T gene in hypertension population may be an important genetic factor and a gender difference in Hypertension in rural areas of Anhui Province. It is suggested that this population should make relevant tests as soon as possible to check whether hyperhomocysteinemia occurs.