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自1973年Ames氏研究利用沙门氏菌和动物肝脏微粒体作致突变性试验(Ames试验)以来,经Ames试验证明了多数致癌物质都有致突变性。进而,Yamasaki和Ames将尿吸附在XAD-2树脂上,用浓缩方法可检出人尿的致突变性,除XAD-2外,也可应用Sep-Pak青绵等浓缩尿,进行Ames试验。有人调查了劳动环境中接触各种有害物质与工人尿致突变性的关系。结果接触组的尿致突变性比非接触组高,分析尿的致突变性对快速筛选所接触的环境化学物质有价值。尿的致突变性受吸烟和饮食习惯的影响,
Since the Ames study of 1973 using Salmonella and animal liver microsomes for mutagenicity tests (Ames test), the Ames test proves that most carcinogens are mutagenic. Furthermore, Yamasaki and Ames adsorbed urine on the XAD-2 resin. The mutagenicity of human urine can be detected by the concentration method. In addition to XAD-2, Sepus Pak cotton and other concentrated urine can also be applied for the Ames test. Someone has investigated the relationship between the exposure to various hazardous substances in the working environment and the urine mutagenicity of workers. Results In the contact group, the mutagenicity of urine was higher than that in the non-contact group. Analyzing the mutagenicity of urine was valuable for the rapid screening of environmental chemicals exposed to it. Mutagenicity of urine is influenced by smoking and eating habits,