原发性色素扩散多见于年轻男性近视眼患者,常合并开角型青光眼。近年来病理学研究阐明它是虹膜神经外胚叶的色素碎片和瞳孔开大肌纤维的增生。引起色素脱失的原因是由于放射状排列的晶体小带纤维束与色素上皮的机械性摩擦所致。一些病例,色素扩散程度甚微,其青光眼则归因于房角的中胚叶缺陷;另一些病例,青光眼的发生与色素扩散程度有直接关系。 Primary pigment hyperplasia more common in young men with myopia, often associated with open-angle glaucoma. Pathological studies in recent years show that it is the iris neuroectodermal pigment fragments and pupil open muscle fiber hyperplasia. The cause of pigment loss is due to the mechanical friction of the radially arranged crystalline ribbon bundles with the pigment epithelium. In some cases, the degree of pigment diffusion is minimal, and the glaucoma is attributed to the mesodermal defect in the corner of the eye. In other cases, the incidence of glaucoma is directly related to the degree of pigment diffusion.