近几年发现的由自然界产生的氨基糖苷类抗生素有三个有趣的特征,即产生菌、耐药性、安全性。大多数较新的氨基糖苷类抗生素来自链霉菌以外的放线菌目(简称稀放)所产生的,而小单孢菌在稀放中居首位。它们常常对某些、甚至多数氨基糖苷类抗生素耐药菌株有效,一般毒性较低。其中以福提霉素(Fortimicin)最为显著。奈良等从橄榄色星状孢小单孢菌(M.olivoasterospora)MK The aminoglycoside antibiotics produced in nature in recent years have three interesting characteristics, namely, producing bacteria, drug resistance, and safety. Most of the newer aminoglycoside antibiotics are from Streptomyces other than Streptomyces (referred to as dilute) produced, and Microtus sp. In the first place in the dilution. They are often effective against some and even most aminoglycoside-resistant strains, generally with low toxicity. Among them, Fortimicin was the most prominent. Nara, etc. from M. olivoasterospora MK