胰岛β细胞功能减退与其受氧化应激损伤有很大的关系,格列齐特因独特的氧自由基清除特性及上调胰岛β细胞内抗氧化酶,保护胰岛β细胞抵抗氧化应激;其高选择结合位点和较少促分泌机制,避免对胰岛细胞过度刺激,减轻氧化应激,应用于T2DM前期及新诊断T2DM患者,有望延缓糖尿病的发生和胰岛β细胞衰竭的速度。 Islet β-cell dysfunction and its oxidative stress damage have a great relationship, Gliclazide due to unique oxygen free radical scavenging properties and up-regulation of pancreatic β-cell antioxidant enzymes, pancreatic β-cell protection against oxidative stress; its high Choose binding sites and less secreting mechanism to avoid over-stimulation of islet cells, reduce oxidative stress, used in pre-T2DM and newly diagnosed T2DM patients, is expected to delay the onset of diabetes and pancreatic β-cell failure speed.