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目的探讨FⅫ基因exon146C/T基因多态性与血栓形成的关联性。方法采用PCR-RFLP法鉴定了92例血栓性脑梗塞患者和87例静脉血栓患者及129例健康人的FⅫ基因exon146C/T基因型及C、T等位基因分布频率,采用多元Logistic非条件回归分析方法,进行多因素分析,解析FⅫ基因46C/T多态性与血栓性脑梗塞、静脉血栓形成的关联性。结果血栓性脑梗塞组和静脉血栓组的C等位基因分布频率均高于对照组,血栓性脑梗塞组的C/C基因型在血栓形成中的危险性是T/T基因型的14.533倍,具有统计学意义;静脉血栓组中C/C基因型P值为0.074(χ2=3.203,OR=2.063,95%CI:0.933-4.559),没有统计学意义。结论中国人群中存在FⅫ46C/T基因多态性位点。FⅫ46C/C基因型可能是脑血栓形成的危险因素,而静脉血栓的形成可能与FⅫ46C/T基因多态性没有关联性。
Objective To investigate the association of exon146C / T gene polymorphism with thrombosis in FⅫ gene. Methods FⅫ gene exon146C / T genotypes and C, T allele frequencies were determined by PCR-RFLP in 92 patients with thrombotic cerebral infarction and 87 patients with venous thrombosis and 129 healthy controls. Multivariate Logistic non-conditional regression Analysis methods, multivariate analysis, analysis of F Ⅻ 46C / T polymorphisms and thrombotic cerebral infarction, venous thrombosis associated. Results The frequencies of C allele in thrombotic cerebral infarction group and venous thrombosis group were higher than those in control group. The risk of thrombosis in C / C genotype of thrombotic cerebral infarction group was 14.533 times that of T / T genotype , With statistical significance. The P value of C / C genotype in venous thrombosis group was 0.074 (χ2 = 3.203, OR = 2.063, 95% CI: 0.933-4.559), which was not statistically significant. Conclusion There are FⅫ46C / T polymorphisms in Chinese population. The F46C / C genotype may be a risk factor for cerebral thrombosis, and the formation of venous thrombus may not be related to the FⅫ46C / T gene polymorphism.