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目的探讨格列本脲治疗永久性新生儿糖尿病(PNDM)的疗效。方法选取2008年2月-2009年5月本院收治并确诊的PNDM患儿4例,应用格列本脲对患儿进行试验性治疗2～3周,对格列本脲治疗有效的患儿进行长期随访,并对其疗效进行分析。结果 4例PNDM患儿中例1对格列本脲治疗有效,完全用格列本脲取代了胰岛素治疗。例4部分有效,运用格列本脲和胰岛素联合进行治疗。例2和例3对格列本脲治疗无效。对格列本脲有效及部分有效的患儿进行长期随访,血糖控制良好,未发现明显不良反应。结论部分PNDM患儿对格列苯脲治疗有效。对临床考虑为PNDM的患儿应尽早进行遗传学分析,以利于临床治疗方案的选择。
Objective To investigate the efficacy of glyburide in the treatment of permanent neonatal diabetes mellitus (PNDM). Methods From February 2008 to May 2009, 4 children with PNDM admitted to our hospital and diagnosed were treated with glibenclamide for 2 to 3 weeks. Patients with glibenclamide-treated children Long-term follow-up, and analysis of its efficacy. Results In 4 children with PNDM, 1 was treated with glibenclamide effectively, and insulin was completely replaced by glibenclamide. Example 4 part of the effective use of glyburide and insulin treatment. Cases 2 and 3 did not respond to glyburide treatment. Long-term follow-up of glyburide effective and partially effective children with good glycemic control and no significant adverse effects were found. Conclusion Some children with PNDM are effective in the treatment of glibenclamide. The clinical consideration for children with PNDM genetic analysis should be conducted as soon as possible to facilitate the choice of clinical treatment options.