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为了现察克拉霉素与羟氨苄青霉素及奥美拉唑联合应用对HP阳性的十二指肠球部溃疡的疗效,把83例符合条件的病人随机分为两组,其中42例口服克拉霉素500mg,羟氨苄青霉素1000mg,2次/d,奥美拉唑20mg,1次/d。另一组41例口服甲硝唑400mg,羟氨苄青霉素1000mg,2次/d,奥美拉唑20mg,1次/d。两组疗程均为1周,1周后继续口服奥美拉唑7d,20mg/d,停奥美拉唑1个月后复查胃镜。结果显示,克拉霉素组HP根除率及溃疡愈合率分别为92.8％及88.1％,明显高于甲硝唑组的80.5％及78.1％,有显著性差异(P<0.05)。提示克拉霉素与羟氨苄青霉素及奥美拉唑合用1周疗法有较理想的溃疡愈合率与HP根除率。
In order to observe the curative effect of clarithromycin combined with amoxicillin and omeprazole on HP-positive duodenal ulcer, 83 eligible patients were randomly divided into two groups, of which 42 patients were oral caclolytic Prime 500mg, amoxicillin 1000mg, 2 times / d, omeprazole 20mg, 1 time / d. Another group of 41 cases of oral metronidazole 400mg, amoxicillin 1000mg, 2 times / d, omeprazole 20mg, 1 / d. The two courses of treatment were 1 week, 1 week after oral omeprazole 7d, 20mg / d, stop omeprazole 1 month after the endoscopy. The results showed that the eradication rate and healing rate of HP in clarithromycin group were 92.8% and 88.1%, respectively, which were significantly higher than 80.5% and 78.1% in metronidazole group (P <0.05). Tip clarithromycin and amoxicillin and omeprazole combined with 1 week therapy has an ideal ulcer healing rate and HP eradication rate.