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人Ⅰ型免疫缺陷病毒(HIV-1)的外膜蛋白gp120在病毒的感染侵入过程中发挥重要的功能[1]。gp120的单克隆抗体在HIV-1感染的诊断和治疗中起着十分重要的作用[2],但鼠源性抗体因在人体内可产生较强的免疫原性,因此限制了它的应用。利用基因工程手段制备单链抗体ScFv可以克服鼠源单
The outer membrane protein gp120 of human immunodeficiency virus type 1 (HIV-1) plays an important role in the process of viral invasion [1]. Monoclonal antibodies against gp120 play a very important role in the diagnosis and treatment of HIV-1 infection [2], but the use of murine antibodies limits their utility due to their strong immunogenicity in humans. The single-chain antibody scFv can be overcome by using genetic engineering