用乙酰乙酸乙酯和异丙叉丙酮为原料合成了α异佛尔酮，再用格氏试剂法将α异佛尔酮转位成β异佛尔酮。然后在特殊的ＭｎⅡ或ＣｏⅡ携氧螯合催化剂作用下，再将其氧化为氧化异佛尔酮。该催化剂氧化效果良好，产率可达到６３％，用格氏试剂法合成β异佛尔酮比用乙二醇合成转化更彻底，产率可达７０％。 Α-isophorone was synthesized from ethyl acetoacetate and isopropylidene acetone, then α-isophorone was translocated to β-isophorone by Grignard reagent method. And then in the special Mn Ⅱ or Co Ⅱ carrying oxygen chelating catalyst, and then oxidized to isophorone oxidation. The catalyst has a good oxidation effect, and the yield can reach 63%. The synthesis of β-isophorone by Grignard reagent is more complete than the conversion with ethylene glycol, and the yield can reach 70%.