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检测CD-1小鼠孕晚期暴露细菌脂多糖(LPS)对其中老年期焦虑和自发性探索活性行为的影响。结果显示,15月龄CD-1小鼠在3个任务中的焦虑水平均较青年组升高,自发性探索活动降低(Ps<0.05)。接受LPS处理的15月龄小鼠与同龄对照组比较,高(50μg·kg-1)和低(25μg·kg-1)剂量组在旷场中的周边时间均显著长,跨格子数显著少(Ps<0.05),高剂量组的直立次数也减少(P<0.05)。在黑白巷中,高剂量组的潜伏期和黑巷时间均显著长于同龄对照组(Ps<0.05)。高剂量组在高架十字迷宫中的直立次数显著少于同龄对照组。上述结果提示CD-1小鼠孕晚期暴露LPS可剂量依赖地加速其中老年期任务特异性焦虑和自发性探索活动行为改变。
To detect the effect of exposure to bacterial lipopolysaccharide (LPS) on the anxiety and spontaneous activity of CD-1 mice during the third trimester of pregnancy. The results showed that the levels of anxiety in 15-day-old CD-1 mice in three tasks were higher than those in youth group, and spontaneous exploration activities were decreased (Ps <0.05). Compared with the same age control group, the 15-month-old LPS-treated mice showed significantly longer peripheral time in the open field and significantly fewer cross-grids in the 50 μg · kg -1 and 25 μg · kg -1 groups (Ps <0.05), and the number of erections in high-dose group also decreased (P <0.05). In black and white alley, latency and black alley time of high dose group were significantly longer than those of the same age control group (P <0.05). The upright number of high-dose plus maze in the high dose group was significantly less than that of the same age control group. The above results suggest that exposure of LPS in the third trimester of CD-1 mice can dose-dependently accelerate their task-specific anxiety and spontaneous exploration of behavioral changes in the elderly.