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目的探讨不同类型心绞痛患者血清脂联素(APN)与肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、高敏C反应蛋白(hsCRP)的水平及相关性。方法采用放射免疫法检测稳定型心绞痛患者(SAP组,35例)、不稳定型心绞痛患者(UAP组,32例)、健康者(对照组,33例)血清APN与TNF-α、IL-6、hsCRP的水平并分别比较其相关性。结果SAP和UAP组血清APN水平均显著低于对照组(P<0.05),UAP组血清APN水平显著低于SAP组(P<0.05);SAP和UAP组血清TNF-α、IL-6、hsCRP水平均显著高于对照组(P<0.05),UAP组血清TNF-α、IL-6、hs-CPR水平均显著高于SAP组(P<0.05);心绞痛患者血清APN与TNF-α、IL-6、hsCRP之间均呈负相关(r=-0.47,r=-0.39,r=-0.34),差异均有统计学意义(P<0.05)。结论心绞痛患者血清APN水平降低,TNF-α、IL-6、hsCRP水平升高,与病情严重程度相一致;APN与TNF-α、IL-6、hsCRP的水平对动脉粥样硬化疾病的发生与发展有预测价值。
Objective To investigate the levels of serum adiponectin (APN), tumor necrosis factor α (TNF-α), interleukin 6 (IL-6) and high sensitivity C-reactive protein (hsCRP) in patients with different types of angina pectoris. Methods Serum levels of APN, TNF-α and IL-6 in patients with stable angina pectoris (SAP group, 35 cases), patients with unstable angina pectoris (UAP group, 32 cases) and healthy controls , HsCRP level and compare their correlation respectively. Results Serum levels of APN in SAP and UAP groups were significantly lower than those in control group (P <0.05), and levels of serum APN in UAP group were significantly lower than those in SAP group (P <0.05). Serum levels of TNF-α, IL-6 and hsCRP (P <0.05). The levels of serum TNF-α, IL-6 and hs-CPR in UAP group were significantly higher than those in SAP group (P <0.05) -6, hsCRP were negatively correlated (r = -0.47, r = -0.39, r = -0.34), the difference was statistically significant (P <0.05). Conclusions The level of serum APN and the level of TNF-α, IL-6 and hsCRP in angina patients are lower than those in patients with angina pectoris. The levels of TNF-α, IL-6 and hsCRP are closely correlated with the severity of the disease. Development has predictive value.