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目的验证高频电刺激丘脑底核治疗帕金森病的疗效及探讨其作用机理。方法应用６－羟基多巴胺（６－ＯＨＤＡ）制备偏侧帕金森病（ＰＤ）大鼠模型，丘脑底核区插入刺激电极进行高频刺激，观察ＰＤ大鼠旋转行为改善程度，检测纹状体多巴胺（ＤＡ）、兴奋性氨基酸即谷氨酸（Ｇｌｕ）和天门冬氨酸（Ａｓｐ）含量，并记录皮质和丘脑底核区脑电图改变情况。结果高频电刺激丘脑底核可使ＰＤ模型鼠旋转行为明显下降；刺激同侧纹状体，ＤＡ含量增加，Ｇｌｕ含量减少，Ａｓｐ含量无变化；脑电图示皮质兴奋性增强，丘脑底核区兴奋性却下降。结论本实验从理论上验证了丘脑底核在帕金森病运动症状调节中的重要作用，提示高频电刺激丘脑底核可能成为治疗帕金森病的最有效方法，并且其作用机理与刺激后ＤＡ、Ｇｌｕ、Ａｓｐ之间的相互作用有关
Objective To verify the efficacy of high frequency electrical stimulation of subthalamic nucleus in the treatment of Parkinson’s disease and to explore its mechanism. Methods 6-hydroxydopamine (6-OHDA) was used in the rat model of hemiparkinsonism (PD). The basal ganglia area was inserted into the stimulation electrode for high-frequency stimulation. The degree of rotation of the PD rats was observed and the striatal dopamine (DA), excitatory amino acids glutamic acid (Glu) and aspartate (Asp) content, and record the cortex and subthalamic nucleus EEG changes. Results High-frequency electrical stimulation of the subthalamic nucleus significantly decreased the rotational behavior of PD rats. The ipsilateral striatum increased DA content, decreased Glu content and Asp content. EEG showed enhanced cortical excitability, District excitability has declined. Conclusion This experiment validates the important role of the subthalamic nucleus in the regulation of motor symptoms of Parkinson’s disease. It suggests that high frequency electrical stimulation of the subthalamic nucleus may become the most effective method for the treatment of Parkinson’s disease. And its mechanism of action is similar to that of DA , Glu, Asp between the interaction