作者研究了口服溴麦角环三肽治疗11例肢端肥大症病人(女7例,男4例)。所有病人均为肢端肥大症活动期。9例作过垂体放疗,其中1例作了部分垂体切除。2例过去未治疗过。溴麦角环三肽5毫克,每6小时一次,在7～11周治疗中,抑制了11个病人中9个病人的血生长激素(GH)水平。另外2人血GH水平无抑制,但其中1例尿中未再测出GH;另1例临床效果良好,同时24小时尿羟脯氨酸排泄减少。6例有糖尿者糖耐量改善,3例达正常。所有有效的病人,过度出汗消失,软组织增厚明量减轻,灵巧性提高,面貌改善。继续治疗时,疗效可维持至少11周。目前尚不清楚用更长期的治疗或增加剂量能否进一步降低血GH水平而不引 The authors studied oral bromocriptine tripeptide treatment of 11 cases of acromegaly patients (7 females, 4 males). All patients were acromegaly active period. Nine patients had pituitary radiotherapy, of which 1 had partial pituitary resection. Two cases were untreated in the past. Bromocriptine tripeptide 5 mg every 6 hours, inhibited blood ghrelin (GH) levels in 9 of 11 patients during 7 to 11 weeks of treatment. The other 2 patients had no inhibition of blood GH level, but 1 of them did not detect GH in urine again. The other 1 patient had good clinical effect and decreased urinary hydroxyproline excretion in 24 hours. 6 cases of diabetic patients with impaired glucose tolerance, 3 cases of normal. All effective patients, excessive sweating disappeared, the amount of soft tissue mitigation reduced, dexterity improved, the appearance of improvement. Continue treatment, the effect can be maintained for at least 11 weeks. It is not yet clear whether longer-term treatment or increasing doses can further reduce blood levels of GH without reference