内皮素(ET)及其受体不仅存在于人和动物的外周组织器官,而且广泛分布于中枢神经系统。给动物不同脑区和脊髓腔注射ET可出现明显的升压效应,促进某些生物活性物质的释放,并引起一系列行为变化。中枢高剂量注射ET可导致脑血管痉挛和脑损伤。内皮素可能作为一种神经肽参与机体多个组织器官,包括中枢神经系统本身机能的调节,其代谢紊乱在某些疾病过程中具有重要的发病学意义。 Endothelin (ET) and its receptor not only exist in human and animal peripheral tissues and organs, but also widely distributed in the central nervous system. The injection of ET into different brain regions and spinal cavities of animals shows obvious boosting effect, promotes the release of certain bioactive substances and causes a series of behavioral changes. Central high-dose injection of ET can lead to cerebral vasospasm and brain damage. Endothelin may serve as a neuropeptide involved in the regulation of many tissues and organs of the body, including the central nervous system itself, and its metabolic disorders have important pathological significance in some diseases.