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乙型肝炎病毒可根据全基因核苷酸序列的异源性大于或等于8%而分为A～H 8个基因型。各基因型的分布有一定的地域性,基因型也与乙型肝炎的发展及转归密切相关。近年来,在乙型肝炎的抗病毒治疗过程中发现,不同乙型肝炎病毒基因型对不同抗病毒药物的应答不尽相同,大多数研究证实基因型A或B对干扰素治疗应答明显好于基因型C或D;但各基因型对拉米夫定治疗应答性争议较大;关于其他药物和其他基因型的研究目前尚少。
Hepatitis B virus can be divided into A ~ H 8 genotypes according to the homology of the whole genome nucleotide sequence is greater than or equal to 8%. The genotype distribution of a certain geographical, genotypes and hepatitis B is also closely related to the development and prognosis. In recent years, during the antiviral treatment of hepatitis B, it was found that different hepatitis B virus genotypes respond differently to different antiviral drugs. Most studies confirm that the genotype A or B response to interferon therapy is significantly better than Genotype C or D; but the genotype response to lamivudine treatment more controversial; on other drugs and other genotypes are currently few.