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糖尿病(diabetes mellitus,DM)是严重危害人类健康的全身性代谢疾病,常发生血液流变学、微循环和细胞代谢的紊乱,导致缺血、缺氧和组织水肿,进而引起血管和神经病变。血管病变常常是糖尿病病人致死、致残的主要原因。血管平滑肌细胞的增殖及表型改变是糖尿病引发动脉粥样硬化性疾病的显著特征,而线粒体在血管平滑肌细胞的增殖过程中起重要作用。因此,探讨糖尿病血管平滑肌细胞与线粒体的关系及机制为糖尿病血管性疾病的治疗提供重要的理论基础,有利于基础研究向临床试用药物研究的转化。
Diabetes mellitus (DM) is a systemic metabolic disease that seriously endangers human health. It often causes disorders of hemorheology, microcirculation and cell metabolism, leading to ischemia, hypoxia and edema of tissue, leading to vascular and neuropathies. Vascular lesions are often the leading cause of death and disability in diabetic patients. Proliferation and phenotypic changes of vascular smooth muscle cells are notable features of diabetes-induced atherosclerotic disease, while mitochondria play an important role in the proliferation of vascular smooth muscle cells. Therefore, to explore the relationship between diabetic vascular smooth muscle cells and mitochondria and the mechanism for the treatment of diabetic vascular disease provide an important theoretical basis, is conducive to basic research to clinical trials of drug conversion.