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目的观察原发性高血压(EH)合并糖耐量减低(IGT)患者血浆肿瘤坏死因子α(TNF-α)和白细胞介素6(IL-6)水平的变化,探讨其与EH合并IGT的关系。方法入选EH患者82例,其中合并IGT者42例,糖耐量正常(NGT)者40例;非EH者80例,其中IGT者40例,NGT者40例。采用ELISA法测定血浆中TNF-α、IL-6含量。结果 EH组TNF-α和IL-6水平高于非EH组[TNF-α(29.61±5.35)比(25.82±4.15)ng/L,IL-6(103.79±21.57)比(83.27±16.27)ng/L,均P<0.05]。所有研究对象中,IGT人群血浆TNF-α、IL-6水平均高于NGT人群。多因素logistic回归分析表明,影响EH合并IGT的因素为TNF-α、IL-6、空腹血糖、餐后2h血糖、体质量指数和收缩压(β分别为0.255、0.061、0.740、1.247、0.247、0.140;均P<0.01)。结论 EH、IGT患者TNF-α和IL-6水平增高。EH合并IGT患者TNF-α和IL-6水平进一步增强。
Objective To observe the changes of plasma levels of tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) in patients with essential hypertension (EH) and impaired glucose tolerance (IGT) . Methods Totally 82 EH patients were enrolled, including 42 with IGT and 40 with normal glucose tolerance (NGT); 80 with non-EH, including 40 with IGT and 40 with NGT. The contents of TNF-α and IL-6 in plasma were measured by ELISA. Results The levels of TNF-α and IL-6 in EH group were significantly higher than those in non-EH group (29.61 ± 5.35 vs 25.82 ± 4.15 ng / L, 103.79 ± 21.57 vs 83.27 ± 16.27, respectively] / L, all P <0.05]. In all subjects, plasma levels of TNF-α and IL-6 in IGT population were higher than those in NGT population. Multivariate logistic regression analysis showed that the factors affecting EH with IGT were TNF-α, IL-6, fasting blood glucose, postprandial blood glucose 2h, body mass index and systolic blood pressure (β = 0.255,0.061,0.740,1.247,0.247, 0.140; all P <0.01). Conclusion EH, IGT patients with elevated levels of TNF-α and IL-6. EH and IGT patients with TNF-α and IL-6 levels were further enhanced.