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目的探讨幽门螺旋杆菌(HP)感染在缺血性中风发生发展中的作用。方法采用ELISA方法检验80例缺血性中风患者和80例健康体检者血清中的抗-HP-IgG,用Western-blot方法检测血清抗CagA抗体以及抗VacA抗体,比较合并HP感染的缺血性中风患者与非HP感染患者之间的差异。结果缺血性中风患者的HP感染率明显高于非缺血性中风患者(65.0%和47.5%,P<0.05),HP感染增加缺血性中风的危险性,其比值比(OR)及95%可信区间(95%CI)为2.05(1.09~3.88);Ⅰ型(Ca-gA+VacA+)HP菌株感染率明显高于其他型,也增加患缺血性中风的危险性,其OR及95%CI是2.29(1.08~4.85)。结论HP感染是缺血性中风的危险因素之一,Ⅰ型(CagA+VacA+)HP菌株可能在缺血性中风发生发展中发挥优势作用。
Objective To investigate the role of Helicobacter pylori (HP) infection in the development of ischemic stroke. Methods Serum anti-Hp-IgG was detected by ELISA in 80 patients with ischemic stroke and 80 healthy subjects. Serum anti-CagA and anti-VacA antibodies were detected by Western-blot. The ischemic Differences between stroke patients and non-HP infected patients. Results The HP infection rate of ischemic stroke patients was significantly higher than that of non-ischemic stroke patients (65.0% and 47.5%, P <0.05). HP infection increased the risk of ischemic stroke, the odds ratio (OR) and 95 The 95% confidence interval (95% CI) was 2.05 (1.09-3.88). The infection rate of type I (Ca-gA + VacA +) HP strains was significantly higher than other types and increased the risk of ischemic stroke. 95% CI is 2.29 (1.08 ~ 4.85). Conclusion HP infection is one of the risk factors of ischemic stroke. Type I (CagA + VacA +) HP strains may play a dominant role in the development of ischemic stroke.