以邻苯二酚(儿茶酚)和乙醛酸为原料,在碱性条件下发生缩合反应,合成了3,4-二羟基扁桃酸,此物质是多种香料和药物合成的重要中间体。通过对反应条件的优化得出:反应温度30℃、反应时间5 h。同时采用碱溶液的部分滴加方式,可使缩合反应在较短的时间内完成,收率达85%以上,未反应的邻苯二酚可以回收。 With catechol (catechol) and glyoxylic acid as raw materials, condensation reaction occurred in alkaline conditions, the synthesis of 3,4-dihydroxymandelic acid, this material is a variety of spices and pharmaceutical synthesis of important intermediates . Through the optimization of the reaction conditions: the reaction temperature is 30 ℃, the reaction time is 5 h. At the same time, partial dropping method of alkali solution can make the condensation reaction be completed in a short time, the yield is more than 85%, unreacted catechol can be recovered.